Medication Adherence and Its Relationship with Glycaemic Control Among Ambulatory Patients with Type 2 Diabetes Mellitus: A Cross-sectional Study in A Primary Care Clinic of a Nigerian Tertiary Hospital
DOI:
https://doi.org/10.5281/zenodo.23635695Keywords:
Type 2 diabetes, Glycaemic control, Medication adherence.Abstract
Background: Achieving target glycaemic control relies heavily on how strictly patients adhere to their prescribed medications, a universal reality for those managing type 2 diabetes mellitus. Maintaining this metabolic balance is the primary defence against the micro and macrovascular complications associated with the disease. This research evaluates the impacts of medication adherence on glycaemic control among patients seeking care at the General Outpatient Clinic of the Federal Medical Centre, Gusau.
Methods: We conducted a hospital-based cross-sectional analysis focusing on adult patients aged 18 and above diagnosed with type 2 diabetes mellitus over a 12-week time frame. A systematic random sampling technique was utilized to select roughly 120 individuals. Two incomplete questionnaires were excluded and 118 completed data of the respondents was analysed. To measure treatment adherence, we deployed the 8-item Morisky Medication Adherence Scale, while an Infopia Clover A1C analyser was used to measure HBA1C of the respondents.
Results: Females respondents constituted the bulk of our cohort at 80 participants (67.8%), and the dominant age bracket was 45 to 64 years, representing 77 participants (66.9%). Among those demonstrating strong adherence to their drug therapy, 35 individual (72.9%) successfully maintained adequate glycaemic control. Conversely,13 individuals (54.2%) of those who poorly adhered to their prescriptions exhibited inadequate glycaemic control. Statistical analysis confirmed a meaningful, direct relationship between medication adherence and glycaemic control (p = 0.014).
Conclusion: This study established a positive correlation connecting strict medication adherence with glycaemic control within the the study population.
References
Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice. 2014;103(2):137-149.
Lovic D, Piperidou A, Zografou I, Grassos H, Pittaras A, Manolis A. The growing epidemic of diabetes mellitus. Current Vascular Pharmacology. 2020;18(2):104-1049.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37(Suppl 1): S81-90.
Dessie G, Mulugeta H, Amare D, Negesse A, Wagnew F, Getaneh T, et al. A systematic analysis on prevalence and sub-regional distribution of undiagnosed diabetes mellitus among adults in African countries. Journal of Diabetes & Metabolic Disorders. 2020; 19:1931-1941.
Zullig LL, Gellad WF, Moaddeb J, Crowley MJ, Shrank W, Granger BB, et al. Improving diabetes medication adherence: successful, scalable interventions. Patient Preference and Adherence. 2015; 9:139-149.
Lam WY, Fresco P. Medication adherence measures: an overview. BioMed Research International. 2015; 2015:1-14.
Othman G, Ali F, Ibrahim MI, Al-Worafi YM, Ansari M, Halboup AM. Assessment of Anti-Diabetic Medications Adherence among Diabetic Patients in Sana’a City, Yemen: A Cross-Sectional Study. Journal of Pharmaceutical Research International. 2020;32(21):114-122.
Williams JL, Walker RJ, Smalls BL, Campbell JA, Egede LE. Effective interventions to improve medication adherence in Type 2 diabetes: a systematic review. Diabetes Management (Lond). 2014;4(1):29-48.
Schwartz DD, Stewart SD, Aikens JE, Bussell JK, Osborn CY, Safford MM. Seeing the person, not the illness: promoting diabetes medication adherence through patient-centered collaboration. Clinical Diabetes. 2017;35(1):35-42.
Al-Haj Mohd MM, Phung H, Sun J, Morisky DE. The predictors to medication adherence among adults with diabetes in the United Arab Emirates. Journal of Diabetes & Metabolic Disorders. 2016; 15:1-9.
Elsous A, Radwan M, Al-Sharif H, Abu Mustafa A. Medications adherence and associated factors among patients with type 2 diabetes mellitus in the Gaza Strip, Palestine. Frontiers in Endocrinology. 2017; 8:100-109.
Polonsky WH, Henry RR. Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors. Patient Preference and Adherence. 2016; 10:1299-1307.
Chatterjee S, Davies MJ. Current management of diabetes mellitus and future directions in care. Postgraduate Medical Journal. 2015;91(1081):612-621.
Sendekie AK, Netere AK, Kasahun AE, Belachew EA. Medication adherence and its impact on glycemic control in type 2 diabetes mellitus patients with comorbidity: A multicenter cross-sectional study in Northwest Ethiopia. PLoS One. 2022;17(9): 1-5.
Iloh GUP. Family functionality, medication adherence and blood glucose control among ambulatory type 2 diabetic patients in a Nigerian hospital. Journal of Basic and Clinical Pharmacy. 2017;8(3):149-153.
Elsous A, Radwan M, Al-Sharif H, Abu Mustafa A. Medications adherence and associated factors among patients with type 2 diabetes mellitus in the Gaza Strip, Palestine. Frontiers in Endocrinology. 2017; 8:100-109
Osuji NA, Ojo OS, Malomo SO, Sogunle PT, Egunjobi AO, Odebunmi OO. Relationship between glycemic control and perceived family support among people with type 2 diabetes mellitus seen in a rich kinship network in Southwest Nigeria. Family Medicine and Community Health. 2018;6(4):168-177.
Kassahun A, Gashe F, Mulisa E, Rike WA. Nonadherence and factors affecting adherence of diabetic patients to anti-diabetic medication in Assela General Hospital, Oromia Region, Ethiopia. Journal of Pharmacy & Bioallied Sciences. 2016;8(2):124-129.
Ibrahim AO, Agboola SM, Elegbede OT, Ismail WO, Agbesanwa TA, Omolayo TA. Glycemic control and its association with sociodemographics, comorbid conditions, and medication adherence among patients with type 2 diabetes in southwestern Nigeria. Journal of International Medical Research. 2021;49(10).1-13
Sada KB, Sabir AA, Sakajiki AM, Umar MT, Abdullahi U, Sikiru YA. Clinical profile of patients with diabetes mellitus in Gusau, Northwestern Nigeria. Annals of African Medicine. 2021;20(2):78-83.
David EA, Aderemi-Williams RI, Soremekun RO, Nasiru IY, Auta A. Glycemic control and its determinants among patients with type 2 diabetes in a specialist hospital in Northeast, Nigeria. South African Journal of Psychiatry. 2019;6(1):1-8.
Wu P, Liu N. Association between patients’ beliefs and oral antidiabetic medication adherence in a chinese type 2 diabetic population. Patient Preference and Adherence. 2016; 10:1161-1167.
Emeka EA, Echendu ST, Iloh GU. Association between Perceived Family Support and the Control of Adult Type 2 Diabetes Mellitus in a Nigerian Tertiary Hospital. International Journal of Family Medicine & Healthcare. 2022;1(1):1-7.
Al-Haj Mohd MM, Phung H, Sun J, Morisky DE. The predictors to medication adherence among adults with diabetes in the United Arab Emirates. Journal of Diabetes & Metabolic Disorders. 2016; 15:1-9.
Ahmed NO, Abugalambo S, Almethen GH. Adherence to oral hypoglycemic medication among patients with diabetes in Saudi Arabia. International Journal of Health Sciences (Qassim). 2017;11(3):45-49.
Emeka EA, Echendu ST, Iloh GU, Umeadi EN, Adinnu KM, Ezeude CM, et al. Association between Perceived Family Support and the Control of Adult Type 2 Diabetes Mellitus in a Nigerian Tertiary Hospital. International Journal of Family Medicine & Healthcare. 2022;1(1):1-7.
Abdulsalam LB, Pitmang S, Sabir A, Olatunji LK. Relationship between family dynamics and glycemic control among adults with type 2 diabetes mellitus presenting at Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. International Archives of Medicine. 2019;12(3):1-8.
Ibrahim AO, Agboola SM, Elegbede OT, Ismail WO, Agbesanwa TA, Omolayo TA. Glycemic control and its association with sociodemographics, comorbid conditions, and medication adherence among patients with type 2 diabetes in southwestern Nigeria. Journal of International Medical Research. 2021;49(10)4-8
Osuji NA, Ojo OS, Malomo SO, Sogunle PT, Egunjobi AO, Odebunmi OO. Relationship between glycemic control and perceived family support among people with type 2 diabetes mellitus seen in a rich kinship network in Southwest Nigeria. Family Medicine and Community Health. 2018;6(4):168-177.
Ayele AA, Tegegn HG, Ayele TA, Ayalew MB. Medication regimen complexity and its impact on medication adherence and glycemic control among patients with type 2 diabetes mellitus in an Ethiopian general hospital. BMJ Open Diabetes Research & Care. 2019;7(1):.5-6
Chin SS, Lau SW, Lim PL, Wong CM, Ujang N. Medication adherence, its associated factors and implication on glycaemic control in patients with type 2 diabetes mellitus: A cross-sectional study in a Malaysian primary care clinic. Malaysian Family Physician. 2023; 18:14-16
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Copyright (c) 2026 Dan-Inna Muhammad Zaharadeen, Abba Kasim Ibrahim, Abubakar Mohammad Song, Yazeed Garba Bala, Dalhatu Abdullahi Aminu, Ahmad Abubakar, Bello Arkilla Magaji, Badru Lawal, Abdullahi Musa Adobanyi, Malami Muhammad Bello., Mikailu Suleman, Kasimu Mamuda, Khadija Muhammad Kanoma, Baura Musatafa Bello, Mansur Abdullahi Maikano, Abdulrasaq Amusa, Abdullahi Ibrahim, Anas Ibrahim Yakubu, Kabir Sada Bello, Umar Abdullahi, Umar Abdlurahman, Bello Alhaji MOHAMMED, Abdullahi Shehu. (Author)
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